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KMID : 0360220090500040630
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 4 p.630 ~ p.634
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Intravitreal Bevacizumab Injection in Adult Coats’Disease
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Park Young-Sook
Sohn Joon-Hong
Lim Han-Woong
Lee Byung-Ro
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Abstract
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Purpose: To report the efficacy of intravitreal bevacizumab injection in adult patients with Coats’disease.
Case summary: Vascular telangiectasia, microaneurysms, circinate hard exudates, and macular edema were shown in the macula of two patients. Vascular abnormality was limited to≤6 clock hours in both cases. In case 1, the temporal retina demonstrates filigree-like vessels and capillary nonperfusion. In case 2, the nasal retina demonstrates aneurysmal dilatation and multiple microaneurysms. Intravitreal bevacizumab injection was administered in both cases. After 1 month, macular edema decreased. Laser photocoagulation was performed for vascular telangiectasia, microaneurysms, and capillary nonperfusion area. Then an additional decrease of macular edema was observed. Fluorescein leakage decreased, as well. After 1 month (case 1) and 2 months (case 2), macular edema increased. The second and third intravitreal reinjections were administered to each patient. Macular edema decreased.
Conclusions: We report two rare cases of Coats’disease in adult patients. Intravitreal bevacizumab injection in patients with Coats’disease can result in a rapid decrease of macular edema, which will then lead to rapid visual recovery and an opportunity for effective laser photocoagulation. We recommend that intraviteal bevacizumab injection be used in combination with laser photocoagulation for the treatment of Coats’disease.
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KEYWORD
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Coats’disease, Intravitreal bevacizumab injection, Laser photocoagulation
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